Elements of natural products chemistry

Forma zajęć:     Wykład 15 h     Laboratorium 30 h    



Laboratory classes will take place on Fridays from 8:15 am till 11:00 am at the organic chemistry lab. (room 224B). 

Lab coats and protective glasses are mandatory!

Students will work in pairs and they will need to isolate, purify and characterize 4 different compounds from natural sources as well as repurify one additional compound provided by a teacher. Each coumpound should be characterised by spectroscipic, phys-chem. or chemical methods (for example mp, bp, n, TLC, MS, NMR...) to confirm their chemical identity and purity.

Students are free to choose which compounds they would isolate. If these are "not standard" products (not described in scripts suggested by a teacher), students should disscuss a possibility of such isolation with a teacher before the lab class.

Isolated compounds should be given to a teacher together with a lab report.

 

Literature:

Medicinal Natural Products: A Biosynthetic Approach, 3rd Edition. Paul M. Dewick, 2009 John Wiley & Sons, Ltd. ISBN: 978-0-470-74168-9

ALKALOIDS – SECRETS OF LIFE. ALKALOID CHEMISTRY, BIOLOGICAL SIGNIFICANCE, APPLICATIONS AND ECOLOGICAL ROLE, Tadeusz Aniszewski, Elsevier, 2007, ISBN-13: 978-0-444-52736-3

The Dictionary of Natural Products (DNP), 

Classics in Spectroscopy. Isolation and Structure Elucidation of Natural Products. Stefan Berger and Dieter Sicker. 2009 WILEY-VCH, ISBN: 978-3-527-32516-0

Natural products isolation. – 2nd ed. / edited by Satyajit D. Sarker, Zahid Latif, Alexander I. Gray. (Methods in biotechnology; 20) ISBN 1-58829-447-1,  ISBN 1-59259-955-9 (eISBN), 2006 Humana Press Inc.

 

http://www.staff.amu.edu.pl/~psorg/serp.pdf 

https://www.researchgate.net/file.PostFileLoader.html?id=54ffff69ef971372238b458a&assetKey=AS%3A273729576210432%401442273625217 

http://disruptechno2.free.fr/FMS/Natural%20product%20isolation%20(Otto%20Sticher).pdf 

https://books.google.pl/books?id=A85gz71Tgy8C&lpg=PR12&ots=TV3FKDaDTn&dq=natural%20products%20isolation&hl=pl&pg=PP1#v=onepage&q=natural%20products%20isolation&f=false

https://books.google.pl/books?id=pfcRQQnVQ78C&lpg=PP1&dq=natural%20products%20isolation&hl=pl&pg=PP4#v=onepage&q=natural%20products%20isolation&f=false

http://walghazzawi.kau.edu.sa/Files/0007119/Files/119837_natural_products.pdf 

https://drive.google.com/open?id=0B7A6tRYHG2mebUhIX1pwRjFNcjQ&authuser=0